Despite recent progress in the identification of genes that regulate longevity, aging remains a mysterious process. One influential hypothesis is the idea that the potential for cell division and replacement are important factors in aging. In this work, we review and discuss this perspective in the context of interventions in mammals that appear to accelerate or retard aging. Rather than focus on molecular mechanisms, we interpret results from an integrative biology perspective of how gene products affect cellular functions, which in (...) turn impact on tissues and organisms. We review evidence suggesting that mutations that give rise to features resembling premature aging tend to be associated with cellular phenotypes such as increased apoptosis or premature replicative senescence. In contrast, many interventions in mice that extend lifespan and might delay aging, including caloric restriction, tend to either hinder apoptosis or result in smaller animals and thus may be the product of fewer cell divisions. Therefore, it appears plausible that changes in the number of times that cells, and particularly stem cells, divide during an organism's lifespan influence longevity and aging. We discuss possible mechanisms related to this hypothesis and propose experimental paradigms. BioEssays 30:567–578, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Jim Joyce has presented an argument for Probabilism based on considerations of epistemic utility [Joyce, 1998]. In a recent paper, I adapted this argument to give an argument for Probablism and the Principal Principle based on similar considerations [Pettigrew, 2012]. Joyce’s argument assumes that a credence in a true proposition is better the closer it is to maximal credence, whilst a credence in a false proposition is better the closer it is to minimal credence. By contrast, my argument in that (...) paper assumed (roughly) that a credence in a proposition is better the closer it is to the objective chance of that proposition. In this paper, I present an epistemic utility argument for Probabilism and the Principal Principle that retains Joyce’s assumption rather than the alternative I endorsed in the earlier paper. I argue that this results in a superior argument for these norms. (shrink)

A brief, non-technical introduction to technical and philosophical aspects of Frege's philosophy of arithmetic. The exposition focuses on Frege's Theorem, which states that the axioms of arithmetic are provable, in second-order logic, from a single non-logical axiom, "Hume's Principle", which itself is: The number of Fs is the same as the number of Gs if, and only if, the Fs and Gs are in one-one correspondence.

In The Varieties of Reference, Gareth Evans argues that the content of perceptual experience is nonconceptual, in a sense I shall explain momentarily. More recently, in his book Mind and World, John McDowell has argued that the reasons Evans gives for this claim are not compelling and, moreover, that Evans’s view is a version of “the Myth of the Given”: More precisely, Evans’s view is alleged to suffer from the same sorts of problems that plague sense-datum theories of perception. In (...) particular, McDowell argues that perceptual experience must be within “the space of reasons,” that perception must be able to give us reasons for, that is, to justify, our beliefs about the world: And, according to him, no state that does not have conceptual content can be a reason for a belief. Now, there are many ways in which Evans’s basic idea, that perceptual content is nonconceptual, might be developed; some of these, I shall argue, would be vulnerable to the objections McDowell brings against him. But I shall also argue that there is a way of developing it that is not vulnerable to these objections. (shrink)

In this exciting new collection, a distinguished international group of philosophers contribute new essays on central issues in philosophy of language and logic, in honor of Michael Dummett, one of the most influential philosophers of the late twentieth century. The essays are focused on areas particularly associated with Professor Dummett. Five are contributions to the philosophy of language, addressing in particular the nature of truth and meaning and the relation between language and thought. Two contributors discuss time, in particular the (...) reality of the past. The last four essays focus on Frege and the philosophy of mathematics. The volume represents some of the best work in contemporary analytical philosophy. (shrink)

Hartry Field has suggested that we should adopt at least a methodological deflationism: [W]e should assume full-fledged deflationism as a working hypothesis. That way, if full-fledged deflationism should turn out to be inadequate, we will at least have a clearer sense than we now have of just where it is that inflationist assumptions ... are needed. I argue here that we do not need to be methodological deflationists. More pre-cisely, I argue that we have no need for a disquotational truth-predicate; (...) that the word true, in ordinary language, is not a disquotational truth-predicate; and that it is not at all clear that it is even possible to introduce a disquotational truth-predicate into ordinary language. If so, then we have no clear sense how it is even possible to be a methodological deflationist. My goal here is not to convince a committed deflationist to abandon his or her position. My goal, rather, is to argue, contrary to what many seem to think, that reflection on the apparently trivial character of T-sentences should not incline us to deflationism. (shrink)

My purpose is to account for some oddities in what Kant did and did not say about "moral worth," and for another in what commentators tell us about his intent. The stone with which I hope to dispatch these several birds is-as one would expect a philosopher's stone to be-a distinction. I distinguish between two things Kant might have had in mind under the heading of moral worth. They come readily to mind when one both takes account of what he (...) actually said about it and notices a fact which he did not seem to notice: namely, that dutiful action- action which, whatever its motive, fulfills a duty-can be over- determined, and determined in particular by both respect for duty and some consortium of inclinations and prudenc. (shrink)

The 1920-1960 period saw the creation of the conditions for a unification of disciplines in the area of evolutionary biology under a limited number of theoretical prescriptions: the evolutionary synthesis. Whereas the sociological dimension of this synthesis was fairly successful, it was surprisingly loose when it came to the interpretation of the evolutionary mechanisms per se, and completely lacking at the level of the foundational epistemological and metaphysical commitments. Key figures such as Huxley, Simpson, Dobzhansky, and Rensch only paid lip (...) service to the conceptual dimension of the evolutionary synthesis, as they eventually realized that a number of evolutionary phenomena could not be explained by its narrow theoretical corpus. Apparently, the evolutionary synthesis constituted a premature event in the development of evolutionary biology. Not only are the real achievements of the evolutionary synthesis in need of reevaluation, but this reassessment also has important implications for the historiography of Darwinism and the current debates about the darwinian movement. (shrink)

The paper formulates and proves a strengthening of ‘Frege’s Theorem’, which states that axioms for second-order arithmetic are derivable in second-order logic from Hume’s Principle, which itself says that the number of Fs is the same as the number ofGs just in case the Fs and Gs are equinumerous. The improvement consists in restricting this claim to finite concepts, so that nothing is claimed about the circumstances under which infinite concepts have the same number. ‘Finite Hume’s Principle’ also suffices for (...) the derivation of axioms for arithmetic and, indeed, is equivalent to a version of them, in the presence of Frege’s definitions of the primitive expressions of the language of arithmetic. The philosophical significance of this result is also discussed. (shrink)

In recent work on Frege, one of the most salient issues has been whether he was prepared to make serious use of semantical notions such as reference and truth. I argue here Frege did make very serious use of semantical concepts. I argue, first, that Frege had reason to be interested in the question how the axioms and rules of his formal theory might be justified and, second, that he explicitly commits himself to offering a justification that appeals to the (...) notion of reference. I then discuss the justifications Frege offered, focusing on his discussion of inferences involving free variables, in section 17 of Grundgesetze, and his argument, in sections 29-32, that every well-formed expression of his formal language has a unique reference. (shrink)

John Etchemendy has argued that it is but "a fortuitous accident" that Tarski's work on truth has any signifance at all for semantics. I argue, in response, that Etchemendy and others, such as Scott Soames and Hilary Putnam, have been misled by Tarski's emphasis on definitions of truth rather than theories of truth and that, once we appreciate how Tarski understood the relation between these, we can answer Etchemendy's implicit and explicit criticisms of neo-Davidsonian semantics.

Frege, famously, held that there is a close connection between our concept of cardinal number and the notion of one-one correspondence, a connection enshrined in Hume's Principle. Husserl, and later Parsons, objected that there is no such close connection, that our most primitive conception of cardinality arises from our grasp of the practice of counting. Some empirical work on children's development of a concept of number has sometimes been thought to point in the same direction. I argue, however, that Frege (...) was close to right, that our concept of cardinal number is closely connected with a notion like that of one-one correspondence, a more primitive notion we might call just as many. (shrink)

The purpose of this note is to present a strong form of the liar paradox. It is strong because the logical resources needed to generate the paradox are weak, in each of two senses. First, few expressive resources required: conjunction, negation, and identity. In particular, this form of the liar does not need to make any use of the conditional. Second, few inferential resources are required. These are: (i) conjunction introduction; (ii) substitution of identicals; and (iii) the inference: From ¬(p (...) ∧ p), infer ¬ p. It is, interestingly enough, also essential to the argument that the ‘strong’ form of the diagonal lemma be used: the one that delivers a term λ such that we can prove: λ = ¬ T(⌈λ⌉); rather than just a sentence Λ for which we can prove: Λ ≡ ¬T(⌈Λ⌉). The truth-theoretic principles used to generate the paradox are these: ¬(S ∧ T(⌈¬S⌉); and ¬(¬S ∧ ¬T(⌈¬S⌉). These are classically equivalent to the two directions of the T-scheme, but they are intuitively weaker. The lesson I would like to draw is: There can be no consistent solution to the Liar paradox that does not involve abandoning truth-theoretic principles that should be every bit as dear to our hearts as the T-scheme. So we shall have to learn to live with the Liar, one way or another. (shrink)

Contrairement à une croyance trop répandue, le darwinisme et son prolongement au XXe siècle — le néo-darwinisme — ne portent pas sur une idée de l'évolution fondée sur la simple notion de « la survie du plus apte ». Si la théorie de la sélection naturelle est partie intégrante du néo-darwinisme, plusieurs de ses fondateurs seront en quête d'une conception beaucoup plus généreuse, pleine et compréhensive de l'évolution. En réalité, la révolution dite darwinienne s'insère au coeur d'une révolution intellectuelle beaucoup (...) plus importante : la révolution transformiste. Avant d'être des darwiniens, de dignes représentants de cette mouvance s'afficheront comme étant des transformistes. Cela signifie que, en plus des mécanismes de l'évolution biologique, d'autres éléments tout aussi cruciaux seront pris en considération`, dans l'élaboration d'une véritable synthèse évolutionniste : les rapports entre l'évolution biologique et l'évolution cosmique ; les interrogations portant sur la question d'une possible direction évolutive ; l'enseignement à tirer pour l'homme de sa place et de son rôle dans la nature. A la croisée de l'histoire, de la philosophie et de la science, cet ouvrage cherche à démontrer, à travers l'analyse des travaux de plusieurs néo-darwiniens de premier plan, que la révolution darwinienne demeurera incomplète aussi longtemps que la révolution transformiste le restera. (shrink)

Mild and moderate mental illnesses can hinder labor force participation, lead to work interruptions, and hamper earning potential. Targeted interventions have proven effective at addressing these problems. But their potential depends on labor protections that enable people to take advantage of these interventions while keeping jobs and income.

Pocock, J. G. A. The myth of John Locke and the obsession with liberalism.--Ashcraft, R. The two treatises and the exclusion crisis: the problem of Lockean political theory as bourgeois ideology.

Depression and the subjective experience of suffering are distinct forms of distress, but they are sometimes commingled with one another. Using a cross-sectional sample of flight attendants, we tested for further empirical evidence distinguishing depression and suffering. Correlations with 15 indices covering several dimensions of well-being indicated that associations with worse well-being were mostly stronger for depression than suffering. There was a large positive correlation between depression and suffering, but we also found evidence of notable non-concurrent depression and suffering in (...) the sample. After dividing participants into four groups that varied based on severity of depression and suffering, regression analyses showed higher levels of well-being among those with both none-mild depression and none-mild suffering compared to those with moderate-severe depression, moderate-severe suffering, or both. All indices of well-being were lowest among the group of participants with moderate-severe depression and moderate-severe suffering. In addition to providing further evidence supporting a distinction between depression and suffering, our findings suggest that concurrent depression and suffering may be more disruptive to well-being than when either is present alone. (shrink)

The paper argues, as against Thau and Caplan, that the traditional interpretation that Frege abandoned his earlier views about identity and identity--statements is correct.

Some years ago, Machery, Mallon, Nichols, and Stich reported the results of experiments that reveal, they claim, cross-cultural differences in speaker’s ‘intuitions’ about Kripke’s famous Gödel–Schmidt case. Several authors have suggested, however, that the question they asked their subjects is ambiguous between speaker’s reference and semantic reference. Machery and colleagues have since made a number of replies. It is argued here that these are ineffective. The larger lesson, however, concerns the role that first-order philosophy should, and more importantly should not, (...) play in the design of such experiments and in the evaluation of their results. (shrink)

A chance-credence norm states how an agent's credences in propositions concerning objective chances ought to relate to her credences in other propositions. The most famous such norm is the Principal Principle (PP), due to David Lewis. However, Lewis noticed that PP is too strong when combined with many accounts of chance that attempt to reduce chance facts to non-modal facts. Those who defend such accounts of chance have offered two alternative chance-credence norms: the first is Hall's and Thau's New Principle (...) (NP); the second is Ismael's General Recipe (IP). Thus, the question arises: Should we adopt NP or IP or both? In this paper, I argue that IP has unacceptable consequences when coupled with reductionism, so we must accept NP alone. (shrink)

The 'substitution argument' purports to demonstrate the falsity of Russellian accounts of belief-ascription by observing that, e.g., these two sentences: (LC) Lois believes that Clark can fly. (LS) Lois believes that Superman can fly. could have different truth-values. But what is the basis for that claim? It seems widely to be supposed, especially by Russellians, that it is simply an 'intuition', one that could then be 'explained away'. And this supposition plays an especially important role in Jennifer Saul's defense of (...) Russellianism, based upon the existence of an allegedly similar contrast between these two sentences: (PC) Superman is more popular than Clark. (PS) Superman is more popular than Superman. The latter contrast looks pragmatic. But then, Saul asks, why shouldn't we then say the same about the former? The answer to this question is that the two cases simply are not similar. In the case of (PC) and (PS), we have only the facts that these strike us differently, and that people will sometimes say things like (PC), whereas they will never say things like (PS). By contrast, there is an argument to be given that (LS) can be true even if (LC) is false, and this argument does not appeal to anyone's 'intuitions'. The main goal of the paper is to present such a version of the substitution argument, building upon the treatment of the Fregan argument against Russellian accounts of belief itself in "Solving Frege's Puzzle". A subsidiary goal is to contribute to the growing literature arguing that 'intuitions' simply do not play the sort of role in philosophical inquiry that so-called 'experimental philosophers' have supposed they do. (shrink)

In his paper “Flaws of Formal Relationism”, Mahrad Almotahari argues against the sort of response to Frege's Puzzle I have defended elsewhere, which he dubs ‘Formal Relationism’. Almotahari argues that, because of its specifically formal character, this view is vulnerable to objections that cannot be raised against the otherwise similar Semantic Relationism due to Kit Fine. I argue in response that Formal Relationism has neither of the flaws Almotahari claims to identify.

This revised workbook is designed for patients' use as they work, either with a qualified mental health professional or on their own, to manage social anxiety. Based on the principles of cognitive-behavioral therapy, the treatment program described is evidence-based and proven effective. Complete with user-friendly forms and worksheets, as well as relatable case examples and chapter review questions, this workbook contains all the tools necessary to help patients manage their anxiety and improve their quality of life.

Why do people in more unequal societies have worse health and shorter lives than those in less unequal ones? Why do more unequal societies tend to have more violence and weaker community life? This paper discusses the research evidence on the psychosocial pathways which suggest how and why we are affected by inequality.How big income differences are in any society seems to serve as an indicator of the scale of social differentiation and social distances within it. The evidence shows that (...) more hierarchical societies incur a wide range of social costs reflecting the corrosive effects of inequality. But why are we so sensitive to inequality? Epidemiological research on health inequalities and the social determinants of health has demonstrated that the quality of the social environment has powerful effects on health. Particularly important are social status, friendship and early childhood experience. The indications are that poor health may share causal pathways with many other social problems associated with relative deprivation - including violence.Summarizing my recent book, The Impact of Inequality , this paper provides an account of how inequality gets under the skin to affect both health and wellbeing. Rather than making comparisons with some impractical state of complete equality, all the evidence presented shows the importance of the differences in inequality between different states of the USA or between different developed market democracies: it shows that even small increases in equality matter. (shrink)

Thirty-four states criminalize HIV in some way, whether by mandating disclosure of one’s HIV status to all sexual partners or by deeming the saliva of HIV-positive persons a “deadly weapon.” In this paper, we argue that HIV-specific criminal laws are rooted in historical prejudice against HIV-positive persons as a class. While purporting to promote public health goals, these laws instead legally sanction discrimination against a class of persons.

Frege's intention in section 31 of Grundgesetze is to show that every well-formed expression in his formal system denotes. But it has been obscure why he wants to do this and how he intends to do it. It is argued here that, in large part, Frege's purpose is to show that the smooth breathing, from which names of value-ranges are formed, denotes; that his proof that his other primitive expressions denote is sound and anticipates Tarski's theory of truth; and that (...) the proof that the smooth breathing denotes, while flawed, rests upon an idea now familiar from the completeness proof for first-order logic. The main work of the paper consists in defending a new understanding of the semantics Frege offers for the quantifiers: one which is objectual, but which does not make use of the notion of an assignment to a free variable. (shrink)

Maybe the most important argument in David Chalmers’s monumental book Constructing the World is the one he calls the ‘Frontloading Argument’, which is used in Chapter 4 to argue for the book’s central thesis, A Priori Scrutability. And, at first blush, the Frontloading Argument looks very strong. I argue here, however, that it is incapable of securing the conclusion it is meant to establish.

This paper dates from about 1994: I rediscovered it on my hard drive in the spring of 2002. It represents an early attempt to explore the connections between the Julius Caesar problem and Frege's attitude towards Basic Law V. Most of the issues discussed here are ones treated rather differently in my more recent papers "The Julius Caesar Objection" and "Grundgesetze der Arithmetik I 10". But the treatment here is more accessible, in many ways, providing more context and a better (...) sense of how this issue relates to broader issues in Frege's philosophy. (shrink)

The paper formulates and proves a strengthening of 'Frege's Theorem', which states that axioms for second-order arithmetic are derivable in second-order logic from Hume's Principle, which itself says that the number of Fs is the same as the number of Gs just in case the Fs and Gs are equinumerous. The improvement consists in restricting this claim to finite concepts, so that nothing is claimed about the circumstances under which infinite concepts have the same number. 'Finite Hume's Principle' also suffices (...) for the derivation of axioms for arithmetic and, indeed, is equivalent to a version of them, in the presence of Frege's definitions of the primitive expressions of the language of arithmetic. The philosophical significance of this result is also discussed. (shrink)

Written as a comment on Crispin Wright's "Vagueness: A Fifth Column Approach", this paper defends a form of supervaluationism against Wright's criticisms. Along the way, however, it takes up the question what is really wrong with Epistemicism, how the appeal of the Sorities ought properly to be understood, and why Contextualist accounts of vagueness won't do.

The main focus of my comments is the role played in Dickie's view by the idea that "the mind has a need to represent things outside itself". But there are also some remarks about her (very interesting) suggestion that descriptive names can sometimes fail to refer to the object that satisfies the associated description.

Psychoanalysis is often equated with Sigmund Freud, but this comparison ignores the wide range of clinical practices, observational methods, general theories, and cross-pollinations with other disciplines that characterise contemporary psychoanalytic work. Central psychoanalytic concepts to do with unconscious motivation, primitive forms of thought, defence mechanisms, and transference form a mainstay of today's richly textured contemporary clinical psychological practice. -/- In this landmark collection on philosophy and psychoanalysis, leading researchers provide an evaluative overview of current thinking. Written at the interface between (...) these two disciplines, the Oxford Handbook of Philosophy and Psychoanalysis contains original contributions that will shape the future of debate. With 34 chapters divided into eight sections covering history, clinical theory, phenomenology, science, aesthetics, religion, ethics, and political and social theory, this Oxford Handbook displays the enduring depth, breadth, and promise of integrating philosophical and psychoanalytic thought. -/- Anyone interested in the philosophical implications of psychoanalysis, as well as philosophical challenges to and re-statements of psychoanalysis, will want to consult this book. It will be a vital resource for academic researchers, psychoanalysts and other mental health professionals, graduates, and trainees. (shrink)

The Evolutionary Synthesis is often seen as a unification process in evolutionary biology, one which provided this research area with a solid common theoretical foundation. As such, neo-Darwinism is believed to constitute from this time onward a single, coherent, and unified movement offering research guidelines for investigations. While this may be true if evolutionary biology is solely understood as centred around evolutionary mechanisms, an entirely different picture emerges once other aspects of the founding neo-Darwinists’ views are taken into consideration, aspects (...) potentially relevant to the elaboration of an evolutionary worldview: the tree of life, the ontological distinctions of the main cosmic entities , the inherent properties of self-organizing matter, evolutionary ethics, and so on. Profound tensions and inconsistencies are immediately revealed in the neo-Darwinian movement once this broader perspective is adopted. This pluralism is such that it is possible to identify at least three distinct and quasi-incommensurable epistemological/metaphysical frameworks as providing a proper foundation for neo-Darwinism. The analysis of the views of Theodosius Dobzhansky, Bernhard Rensch, and Ernst Mayr will illustrate this untenable pluralism, one which requires us to conceive of the neo-Darwinian research agenda as being conducted in more than one research programme or research tradition at the same time. (shrink)

Scaffolds are fundamental to many cellular signaling pathways. In this essay, a novel class of scaffolds are proposed, whose action bears striking resemblance to kinetic proofreading. Commonly, scaffold proteins are thought to work as tethers, bringing different components of a pathway together to improve the likelihood of their interaction. However, recent studies show that the cytoskeletal scaffold, anillin, supports contractile signaling by a novel, non‐tethering mechanism that controls the membrane dissociation kinetics of RhoA. More generally, such proof‐reading‐like scaffolds are distinguished (...) from tethers by a rare type of cooperativity, manifest as a super‐linear relationship between scaffold concentration and signaling efficiency. The evidence for this hypothesis is reviewed, its conceptual ramifications are considered, and research questions for the future are discussed. (shrink)

Using the case of an industrial accident involving a killer robot, the author successfully combines technical and ethical concepts to present to students and professionals real-life issues that they may one day have to confront.

This book offers a thorough reanalysis of Charles Darwin's Origin of Species, which for many people represents the work that alone gave rise to evolutionism. Of course, scholars today know better than that. Yet, few resist the temptation of turning to the Origin in order to support it or reject it in light of their own work. Apparently, Darwin fills the mythical role of a founding figure that must either be invoked or repudiated. The book is an invitation to move (...) beyond what is currently expected of Darwin's magnum opus. Once the rhetorical varnish of Darwin's discourses is removed, one discovers a work of remarkably indecisive conclusions. The book comprises two main theses: The Origin of Species never remotely achieved the theoretical unity to which it is often credited. Rather, Darwin was overwhelmed by a host of phenomena that could not fit into his narrow conceptual framework. In the Origin of Species, Darwin failed at completing the full conversion to evolutionism. Carrying many ill-designed intellectual tools of the 17th and 18th centuries, Darwin merely promoted a special brand of evolutionism, one that prevented him from taking the decisive steps toward an open and modern evolutionism. It makes an interesting read for biologists, historians and philosophers alike. (shrink)

Hartry Field has suggested that we should adopt at least a methodological deflationism: "[W]e should assume full-fledged deflationism as a working hypothesis. That way, if full-fledged deflationism should turn out to be inadequate, we will at least have a clearer sense than we now have of just where it is that inflationist assumptions... are needed". I argue here that we do not need to be methodological deflationists. More precisely, I argue that we have no need for a disquotational truth-predicate; that (...) the word 'true', in ordinary language, is not a disquotational truth-predicate; and that it is not at all clear that it is even possible to introduce a disquotational truth-predicate into ordinary language. If so, then we have no clear sense how it is even possible to be a methodological deflationist. My goal here is not to convince a committed deflationist to abandon his or her position. My goal, rather, is to argue, contrary to what many seem to think, that reflection on the apparently trivial character of T-sentences should not incline us to deflationism. (shrink)